Their new system does all of that and more. Jia's team has pioneered a faster light-field system that provides greater resolution and minimizes photo damage. Conventional 3D imaging technologies rely on time-consuming, redundant scanning-based techniques, which can result in damaged cells and compromised images. Jia's new system builds on his lab's growing body of work in next-generation imaging systems. They described their system in the journal Biosensors and Bioelectronics. Led by Coulter BME Assistant Professor Shu Jia, their custom-built microscope can reconstruct a comprehensive 3D representation with a single camera image. Now, a team of Georgia Tech researchers has built a better system to quickly produce high-resolution 3D images in real time, providing a quantitative analysis of organoids. Conventional methods are time consuming and don't adequately capture the fast, dynamic, sometimes unpredictable cellular and tissue processes of these model systems. Fluorescence 3D microscopy has helped transform the study of organoids at the cellular and subcellular levels - though with a few drawbacks. The trick is in getting those detailed images. "It can tell us how diseases progress, or how mechanical forces and certain drugs may change or affect cellular behavior." Coulter Department of Biomedical Engineering at Georgia Tech and Emory University.
Chair in Regenerative Engineering and Medicine in the Wallace H. "Getting detailed 3D images of these miniature models of organs, and getting a good look at how they change under different conditions or stimulation, can tell us a lot about how the body works," said Shuichi Takayama, professor and Price Gilbert Jr.
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